Journal: Clinical Psychopharmacology and Neuroscience
Article Title: In Silico Model-driven Assessment of the Effects of Brain-derived Neurotrophic Factor Deficiency on Glutamate and Gamma-Aminobutyric Acid: Implications for Understanding Schizophrenia Pathophysiology
doi: 10.9758/cpn.2017.15.2.115
Figure Lengend Snippet: Workflow of the study methodology. (A) Multiple databases like Panther pathway, Reactome and BioModels were used for building model sub-components. (B) System Biology Markup Language (SBML) squeezer was used to generate the kinetic laws. Initial values were defined from BioGPS database. (C) The SBML model was imported in COPASI. Global constants were defined from BRENDA and DOQCS. Unavailable values were optimized after assigning parameters and defining ordinary differential equations. Analyses included steady state stability, perturbation time-course simulation and sensitivity analysis.
Article Snippet: Publicly available databases such as Panther pathway, Reactome and BioModels were used for SBML model sub-components.
Techniques: